Matthew Perry
New Show: 'Studio 60 on the Sunset Strip'
New Role: Perry plays Matt Albie, a former writer for a live sketch comedy show, who is asked to come back to run it with his pal Danny Tripp (Bradley Whitford.)
Claim to Fame: Bringing favorite funnyman Chandler Bing to life on a little show called 'Friends'
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Ted Danson
New Show: 'Help Me Help You'
New Role: Danson stars as Dr. Bill Hoffman, a cranky therapist who leads a weekly group therapy session of colorful characters. The doctor is in ... charge.
Claim to Fame: Playing ladies man and barkeeper Sam Malone on 'Cheers'
Calista Flockhart
New Show: 'Brothers & Sisters'
New Role: Flockhart stars as Kitty Walker, a conservative radio host who must deal with her difficult siblings and parents in this new drama.
Claim to Fame: Playing the lead legal eagle on 'Ally McBeal'
Tina Fey
New Show: '30 Rock'
New Role: In this new sitcom, life imitates art when former 'Saturday Night Live' head writer Fey stars as the head writer of a live variety show.
Claim to Fame: Her stint as weekend update anchor on 'SNL'
Brad Garrett
New Show: 'Til Death'
New Role: In this new comedy, Garrett plays cynical married man and high school history teacher Eddie Stamm. He and his wife, Joy, live next door to happy newlyweds.
Claim to Fame: Starring as lovable cop Robert Barone on 'Everybody Loves Raymond'
John Lithgow
New Show: '20 Good Years'
New Role: Lithgow and Jeffrey Tambor ('Arrested Development') co-star as best friends who suddenly realize they only have twenty good years left in life and determine to make best of them.
Claim to Fame: Playing alien-in-disguise Dr. Dick Solomon on '3rd Rock from the Sun'
Rachel Griffiths
New Show: 'Brothers & Sisters'
New Role: Griffiths plays Sarah Walker, a corporate executive who returns to the family business so she can concentrate on her marriage.
Claim to Fame: Winning Emmys for her portrayal of Brenda Chenowith on 'Six Feet Under'
Anne Heche
New Show: 'Men in Trees'
New Role: Heche stars as Marin Frist, a relationship counselor who moves to Alaska after her own relationship crumbles.
Claim to Fame: Playing Amanda Hayes on 'Everwood' and Melanie West on 'Ally McBeal'
Bradley Whitford
New Show: 'Studio 60 on the Sunset Strip'
New Role: Whitford is Daniel Tripp, a former director for a live sketch comedy show who is asked to come back to run it with his pal Matt Albie (Matthew Perry.)
Claim to Fame: Playing Deputy White House Chief Josh Lyman on 'West Wing'
Kim Raver
New Show: 'The Nine'
New Role: Raver stars as Kathryn Hale, an assistant D.A. in Los Angeles who, along with eight other people, is held hostage in a bank for 52 hours.
Claim to Fame: Winning Jack Bauer's heart as DOD liaison Audrey Raines on '24'
Tim Daly
New Show: 'The Nine'
New Role: Daly is Nick Cavanaugh, a troubled LAPD homicide detective who is one of nine people held hostage.
Claim to Fame: Playing straight-laced pilot Joe Hackett on 'Wings'
Scott Wolf
New Show: 'The Nine'
New Role: Wolf plays Jeremy Kates, a doctor who is held hostage in a Los Angeles bank for 52 hours and forms a bond with the other eight victims.
Claim to Fame: Roles as Bailey Salinger on 'Party of Five' and Dr. Jake Hartman on 'Everwood'
Kyle Chandler
New Show: 'Friday Night Lights'
New Role: Chandler leads the team as Eric Taylor, the coach of a high-stakes high school football team in small Texas town.
Claim to Fame: Playing Gary Hobson on 'Early Edition'
Gerald McRaney
New Show: 'Jericho'
New Role: McRaney stars as the mayor of a small Kansas town dealing with the sudden appearance of a mushroom cloud on the horizon.
Claim to Fame: Playing Major John MacGillis on 'Major Dad'
Victor Garber
New Show: 'Justice'
New Role: Garber joins a crack legal team as Los Angeles lawyer Ron Trott, tackling high-profile cases.
Claim to Fame: Butt-kicking double agent, and dad, Jack Bristow on 'Alias'
Donnie Wahlberg
New Show: 'Runaway'
New Role: Wahlberg leads the cast as Paul Rader, a man falsely acccused of murder and running from the law with his wife and three kids.
Claim to Fame: Playing 2nd Lt. C. Carwood Lipton on 'Band of Brothers'
Wendie Malick
New Show: 'Big Day'
New Role: Malick plays Jane in this new comedy about the wedding day of a young couple. 'Big Day' will premiere later this season.
Claim to Fame: Starring as the randy Nina Van Horn on 'Just Shoot Me'
Milo Ventimiglia
New Show: 'Heroes'
New Role: Ventimiglia stars as a hospice nurse who thinks he can fly in this new drama about real life superheroes.
Claim to Fame: Playing Jess Mariano on 'Gilmore Girls'
Jeremy Sisto
New Show: 'Kidnapped'
New Role: Sisto plays Knapp, a former FBI agent who now works privately to recover kidnap victims.
Claim to Fame: Playing mentally ill Billy Chenowith on 'Six Feet Under'
Greg Grunberg
New Show: 'Heroes'
New Role: Grunberg plays LAPD officer Matt Parkman in this new drama about real-life superheroes.
Claim to Fame: Good-guy agent Eric Weiss on 'Alias'
Where Are In2TV Stars Now?
· William Shatner
· Don Johnson
Fall TV Preview
Get the scoop on all the new and returning shows, see photo galleries and take quizzes.
· Quiz: Cliffhanger I.Q.
· Cable TV Premiere Schedule
· TV Spoilers: Get Your Fix!
